Phosphatase tensin-type domain
WebMar 1, 2024 · β-Amyloid Precursor Protein Intracellular Domain Controls Mitochondrial Function by Modulating Phosphatase and Tensin Homolog-Induced Kinase 1 Transcription in Cells and in Alzheimer Mice Models Overall, we delineate a molecular cascade presenilins-AICD-Forkhead box O3a linking parkin to Pink-1. WebApr 3, 2024 · PTEN phosphatase and tensin homolog Gene ID: 5728, updated on 3-Apr-2024 Gene type: protein coding Also known as: BZS; DEC; CWS1; GLM2; MHAM; TEP1; MMAC1; …
Phosphatase tensin-type domain
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Web132 rows · Apr 4, 2024 · Summary. This gene encodes a phosphatase with dual activity against phospholipids and proteins, and acts as a tumor-suppressor. The protein contains … WebJun 27, 2006 · The pathology involves the loss of dopaminergic neurons in the substantia nigra and the presence of Lewy bodies (intraneuronal accumulations of aggregated proteins), in surviving neurons in various areas of the brain. PARK19A is characterized by onset of parkinsonian symptoms in the first or second decade of life.
WebContains 1 phosphatase tensin-type domain. Domain. The C2 domain binds phospholipid membranes in vitro in a Ca(2+)-independent manner; this binding is important for its tumor suppressor function. Post-translational modifications. Constitutively phosphorylated by CK2 under normal conditions. Phosphorylated in vitro by MAST1, MAST2, MAST3 and STK11. WebGene Variant Descriptions. PTEN D24H lies within the phosphatase tensin-type domain of the Pten protein (UniProt.org). D24H results in reduced phosphatase activity in a yeast assay ( PMID: 29706350 ), and results in abnormal cellular localization and loss of PI3K/AKT/MTOR pathway inhibition, as indicated by increased expression of S6rp in ...
WebFeb 17, 2024 · Tensin was first reported in 1991 as an actin-binding focal-adhesion protein containing a Src homology 2 (SH2) domain, a newly identified binding motif specific for phosphotyrosine (pTyr) at the time, suggesting an interesting role of tensin in bridging signal transduction pathways with the cytoskeletal networks ( Davis et al., 1991 ). WebGene Variant Descriptions. PTEN H93Q lies within the phosphatase tensin-type domain of the Pten protein (UniProt.org). H93Q demonstrates Pten protein stability similar to wild-type protein ( PMID: 32350270, PMID: 32366478 ), however, results in a partial loss of ability to rescue spheroid formation ( PMID: 32366478 ), fails to suppress Akt ...
WebTensins constitute an eukaryotic family of lipid phosphatases that are defined by the presence of two adjacent domains: a lipid phosphatase domain and a C2-like domain. The …
WebEnables lipid phosphatase activity. Acts upstream of or within several processes, including lifelong otolith mineralization; negative regulation of angiogenesis; and phosphatidylinositol dephosphorylation. Predicted to be located in PML body and cytoplasm. shut down flip 4WebPhosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchanger factor 2 (PREX2) is a novel regulator of the small guanosine triphosphatase Rac, and has been observed to be implicated in human cancer by inhibiting the activity of phosphatase and tensin homolog (PTEN), thus upregulating the activity of the phosphoinositide 3-kinase (PI3K) signaling … the oxford handbook of cyberpsychology pdfWebPTEN I135V lies within the phosphatase tensin-type domain of the Pten protein (UniProt.org). I135V demonstrates Pten protein stability ( PMID: 32350270 , PMID: … the oxford handbook of cultural sociology pdfWebphosphatase and tensin homolog, b-catenin, p53, endometrial carcinoma. C ancer of the uterine corpus is the most common gynecologic malignancy in the U.S., with approximately 40,880 cases diag-nosed in 2006.1 The incidence of endometrial carcinoma (EC) also has risen each year in Japan over 30 years from 10% in 1983 to 45% shutdown fmc from clishutdown force restartPhosphatase and tensin homolog (PTEN) is a phosphatase in humans and is encoded by the PTEN gene. Mutations of this gene are a step in the development of many cancers, specifically glioblastoma, lung cancer, breast cancer, and prostate cancer. Genes corresponding to PTEN (orthologs) have been … See more PTEN protein acts as a phosphatase to dephosphorylate phosphatidylinositol (3,4,5)-trisphosphate (PtdIns (3,4,5)P3 or PIP3). PTEN specifically catalyses the dephosphorylation of the 3` phosphate of the See more The structure of the core of PTEN (solved by X-ray crystallography, see figure to the upper right ) reveals that it consists primarily of a phosphatase domain, and a C2 domain: the phosphatase domain contains the active site, which carries out the See more PTEN inhibitors Bisperoxovanadium compounds may have a neuroprotective effect after CNS injury. PTEN is inhibited by See more PTEN (gene) has been shown to interact with: • CSNK2A2, • CSNK2A1, • MAGI3 • MVP, • NEDD4, See more Cancer PTEN is one of the most commonly lost tumor suppressors in human cancer; in fact, up to 70% of men with prostate cancer are estimated to have lost a copy of the PTEN gene at the time of diagnosis. A number of studies … See more Cell lines with known PTEN mutations include: • prostate: LNCaP, PC-3 • kidney: 786-O • glioblastoma: U87MG • breast : MB-MDA-468, BT549 See more • Multiple hamartoma syndrome See more shutdown forceWebJan 2, 2024 · Phosphatase and tensin homolog deleted on chromosome 10 ( PTEN ) encodes a 403-amino acid protein with an amino-terminal domain that shares sequence … shutdown flights