WebAntigen Molecular Weight: 330 kDa; predicted 519 kDa Depositors Notes: This antibody recognizes the ectodomain of megalin (gp330) and is useful for endocytic uptake … WebDent disease (DD), an X-linked renal tubulopathy, is mainly caused by loss-of-function mutations in CLCN5 (DD1) and OCRL genes. CLCN5 encodes the ClC-5 antiporter that in proximal tubules (PT) participates in the receptor-mediated endocytosis of low molecular weight proteins. Few studies have analyzed the PT expression of ClC-5 and of megalin …
The Role of Megalin in the Transport of Gentamicin Across
Disfunction in the LRP2-mediated endocytic trafficking and endocytic capacity in the proximal tubule can result in low molecular weight proteinuria, which is a hallmark of many diseases. Mutations in the LRP2 gene are associated with Donnai-Barrow syndrome. Dent's Disease (Dent 1) is associated with a drop … Meer weergeven Low density lipoprotein receptor-related protein 2 also known as LRP-2 or megalin is a protein which in humans is encoded by the LRP2 gene. Meer weergeven LRP2 was identified as the antigen of rat experimental membranous nephropathy (Heyman nephritis) and originally named gp330 and subsequently megalin and later LRP2. LRP2/megalin is a multiligand binding receptor found in the plasma membrane of … Meer weergeven LRP2 has been shown to associate with the following proteins in the plasma membrane/cytosol of cells: • CUBAM, • DAB2, Meer weergeven • Longoni M, Kantarci S, Donnai D, Pober BR (August 2008). "Donnai-Barrow Syndrome". In Adam MP, Mirzaa GM, Pagon RA, Wallace SE, Bean LJ, Gripp KW, et al. … Meer weergeven examples of ethical ramifications
The Amino Acid Masses - Expasy
Web11 jul. 2014 · The megalin gene encodes an extremely large glycoprotein (≈600 kDa), consisting of a large extracellular domain, small transmembrane domain, and … Web3 mrt. 2024 · Megalin expression was regulated and suppressed by 25-hydroxyvitamin D (25D) in cell lines, patient-derived prostate epithelial cells, and prostate tissue explants. … Web24 jan. 2001 · We present the crystal structure at 2.7 angstrom resolution of the human antibody IgG1 b12. Antibody b12 recognizes the CD4-binding site of human immunodeficiency virus-1 (HIV-1) gp120 and is one of only … examples of ethical knowing in nursing