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Megalin molecular weight

WebAntigen Molecular Weight: 330 kDa; predicted 519 kDa Depositors Notes: This antibody recognizes the ectodomain of megalin (gp330) and is useful for endocytic uptake … WebDent disease (DD), an X-linked renal tubulopathy, is mainly caused by loss-of-function mutations in CLCN5 (DD1) and OCRL genes. CLCN5 encodes the ClC-5 antiporter that in proximal tubules (PT) participates in the receptor-mediated endocytosis of low molecular weight proteins. Few studies have analyzed the PT expression of ClC-5 and of megalin …

The Role of Megalin in the Transport of Gentamicin Across

Disfunction in the LRP2-mediated endocytic trafficking and endocytic capacity in the proximal tubule can result in low molecular weight proteinuria, which is a hallmark of many diseases. Mutations in the LRP2 gene are associated with Donnai-Barrow syndrome. Dent's Disease (Dent 1) is associated with a drop … Meer weergeven Low density lipoprotein receptor-related protein 2 also known as LRP-2 or megalin is a protein which in humans is encoded by the LRP2 gene. Meer weergeven LRP2 was identified as the antigen of rat experimental membranous nephropathy (Heyman nephritis) and originally named gp330 and subsequently megalin and later LRP2. LRP2/megalin is a multiligand binding receptor found in the plasma membrane of … Meer weergeven LRP2 has been shown to associate with the following proteins in the plasma membrane/cytosol of cells: • CUBAM, • DAB2, Meer weergeven • Longoni M, Kantarci S, Donnai D, Pober BR (August 2008). "Donnai-Barrow Syndrome". In Adam MP, Mirzaa GM, Pagon RA, Wallace SE, Bean LJ, Gripp KW, et al. … Meer weergeven examples of ethical ramifications https://andygilmorephotos.com

The Amino Acid Masses - Expasy

Web11 jul. 2014 · The megalin gene encodes an extremely large glycoprotein (≈600 kDa), consisting of a large extracellular domain, small transmembrane domain, and … Web3 mrt. 2024 · Megalin expression was regulated and suppressed by 25-hydroxyvitamin D (25D) in cell lines, patient-derived prostate epithelial cells, and prostate tissue explants. … Web24 jan. 2001 · We present the crystal structure at 2.7 angstrom resolution of the human antibody IgG1 b12. Antibody b12 recognizes the CD4-binding site of human immunodeficiency virus-1 (HIV-1) gp120 and is one of only … examples of ethical knowing in nursing

Functional interaction of megalin with the megalinbinding protein ...

Category:Megalin and cubilin in proximal tubule protein …

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Megalin molecular weight

Guanosine C10H13N5O5 - PubChem

Web7 sep. 2024 · Megalin is an endocytic receptor abundantly expressed in proximal tubular epithelial cells and other calciotropic extrarenal cells expressing vitamin D metabolizing enzymes, such as bone and parathyroid cells. Web7 mrt. 2024 · Purified human renal megalin and CUBAM, 10 μg/ml in 10 mM sodium acetate pH 5.0, were immobilized to a level of 2400 RU in flow cells 2 and 3, respectively. Any remaining active groups were blocked by a 7 min injection of 1 M ethanolamine pH 8.5. Flow cell 1 was activated and blocked to serve as a reference cell.

Megalin molecular weight

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Web19 uur geleden · The defect of LRP2/megalin clearance pathway in the kidney may cause proximal renal tubular acidosis type 2 (Fanconi’s syndrome), with low-molecular weight protein loss.(3 3 Flemming J, Marczenke M, Rudolph IM, Nielsen R, Storm T, Erik IC, et al. Induced pluripotent stem cell-based disease modeling identifies ligand-induced decay of … WebSirolimus is a new and potent immunosuppressive agent. Recently, increased proteinuria has been recognized as an important complication. However, the mechanism thereof has …

Web1 nov. 2024 · It's a high molecular weight (about 600-kD) glycoprotein from the low-density lipoprotein (LDL) receptor family, expressed by various tissues. Megalin also constitutes … WebBiol Res 44: 89-105, 2011 ARTICLES . New Insights into the Roles of Megalin/LRP2 and the Regulation of its Functional Expression . María-Paz Marzolo 1,2 * and Pamela Farfán …

Web14 mrt. 2024 · Megalin is a single transmembrane protein consisting of 4655 amino acids with a molecular weight of 600 kDa. It has a large extracellular domain, a transmembrane region, and a small intracellular tail of 209 amino acids. It was originally known as glycoprotein 330 [ 16 ]. Web19 mei 2015 · Megalin is expressed in human placenta, and it is reasonable to speculate, given its role in renal AG uptake, that it is similarly involved in placental transport. ... Immunoblot analysis of BeWo cells grown on uncoated Transwell plates demonstrated the presence of a distinct band at a molecular weight greater than 225 kDa.

WebMegalin is also critical to reuptake multiple ligands, including vi-tamin-D binding proteins, retinol binding proteins, lipo-proteins and sterols. The defect of LRP2/megalin clearance …

WebGentamicin C21H43N5O7 CID 3467 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities, safety ... brush wolf 72Web11 mei 2024 · A common characteristic of several LRP2/megalin ligands in the kidney is their nature as low-molecular weight transport proteins for lipids, vitamins, and hormones. These ligands include the vitamin D-binding protein (DBP), the retinol-binding protein (RBP), transcobalamin, plasma carriers for vitamins D, A, and B12, respectively [9, 21, 70]. brush wolf 7200WebMegalin, a multi-ligand endocytic receptor, ... It's a high molecular weight (about 600-kD) glycopro-tein from the low-density lipoprotein (LDL) receptor family, expressed examples of ethical practice in the workplaceWebThough beta-actin has a molecular weight of 42 kDa, degradation by apoptosis will produce 38-41 kDa fragments on a Western blot. Proteintech’s monoclonal beta-actin … examples of ethical principles in nursingWeb1 mrt. 2011 · Body weight (kg) 92 ± 16 72 ± 11 ... β2MG is part of the MHC class I molecule and is readily filtered by the renal glomerulus. Once in the renal tubular fluid, β2MG binds to the surface receptor megalin on proximal tubular epithelial cells and is reabsorbed and degraded in these cells. brush wolf 7201lfWeb18 mrt. 2024 · Megalin is a giant membrane glycoprotein originally identified as the Heymann nephritis antigen in rats. Initial purification by gel electrophoresis suggested a … brush wolf 4800xWeb21 jul. 2016 · Megalin is a cell membrane protein also known as Low Density Lipoprotein (LDL) receptor-related protein 2 (LRP-2) or Glycoprotein 330 (gp 330) and is a large membrane-type single transmembrane-type glycoprotein with a molecular weight of approximately 600 KDa. Megalin has an extracellular region having four functional … examples of ethical relativism today