WebThe present study explores the responses of the hypoxia-inducible factor-1α (HIF-1α) to cold, freezing and anoxia exposures in the freeze tolerant goldenrod gall fly larva, Eurosta solidaginis. Reverse transcription-PCR was used to quantify hif-1α transcript levels; transcripts were significantly elevated by ∼70% in chilled (3 ∘ C ... Web9 de jun. de 2024 · HIF family members function as transcriptional regulators of hypoxia (12–14).Under hypoxic conditions, HIF-1α subunits are stabilized and accumulate in the nucleus where they dimerize with …
HIF-1α pathway: role, regulation and intervention for cancer therapy
Web15 de fev. de 2008 · Figure 2. HIF-1 α controls metabolic and pH-regulating pathways. Cells respond to hypoxia by HIF-1 α -mediated upregulation of glucose transporters (Glut-1 and Glut-3) and enzymes of glycolysis ... WebExpressão imunohistoquímica do fator indutor de hipóxia 1-alfa (HIF-1α) em pacientes com câncer de mama localmente avançado Immunohistochemical expression of hypoxia-inducible factor 1-alpha (HIF-1α) in locally advanced breast … iphone 13 美元
HIF‐1α ameliorates tubular injury in diabetic …
Web16 de jul. de 2024 · We intratracheally challenged Hif1α fl/fl and Hif1α fl/fl LysM Cre mice with E. coli or LPS to analyze lung and spleen inflammatory responses. Flow cytometry was used to analyze the changes of α7 nAChR + CD11b + cells in the lung and spleen. Double knockout of Chrna7 and Itgam mice were used to examine expression of HIF-1α during … Web25 de mar. de 2024 · HIF-1α, an essential transcription factor under hypoxic condition, is indispensable for chondrocytes during skeletal development but its expression and roles in articular chondrocytes are yet to ... Web21 de jul. de 2011 · Dominant-negative forms of hif-1αa and hif-1αb were generated using primers amplifying DNA corresponding to amino acids 1-330 of human HIF-1α. 32 Dominant-active forms of hif-1αa and hif-1αb were generated by successive rounds of site-directed mutagenesis. 20,33,34 In each round, one of the hydroxylation sites was … iphone 13 芯片