WebSep 9, 2015 · FUS(全称为fused in sarcoma/translocated in liposarcoma,FUS/TLS)是一个多功能的DNA/RNA结合蛋白,主要定位于细胞核,但可以在细胞核与细胞质中穿梭 … WebThe RRM domain of human fused in sarcoma protein reveals a non-canonical nucleic acid binding site. Xuehui Liu, Chunyan Niu, Jintao Ren, Jiayu Zhang, Xiaodong Xie, Haining Zhu, Wei Feng, Weimin Gong. Research output: Contribution to journal › Article › peer-review. 41 Scopus citations.
Fused in sarcoma regulates DNA replication timing and …
WebMar 17, 2024 · FUS (Fused in Sarcoma) is a member of a family of RNA-binding proteins with roles in transcription, RNA processing, RNA transport, and translation. Mutations in FUS, including R521C, are linked to rare familial cases of ALS. A transgene containing myc-tagged human FUS with the R521C mutation and an upstream Lox-P flanked stop … WebNov 30, 2024 · 相似的,FUS (fused in sarcoma)倾向于结合到环化接合位点两侧的内含子 图2 环状RNA 形成的环化模型 [36] 序列来影响环状RNA 的形成 。 ... 并且,植物中的环状RNA 也 以在体内或体外翻译[130] ,在果蝇中还发现一类可利 [114] [114] [142] 具有保守性 、发育阶段特异性 和 ... liteline track system
Sarcoma - an overview ScienceDirect Topics
WebFused in sarcoma (FUS) encodes an RNA-binding protein with diverse roles in transcriptional activation and RNA splicing. While oncogenic fusions of FUS and transcription factor DNA-binding domains are associated with soft tissue sarcomas, dominant mutations in FUS can cause amyotrophic lateral sclerosis. FUS has also been … WebJul 5, 2024 · High-speed AFM revealed the conformational change of fused in sarcoma (FUS) from a compact to an extended structure upon binding of non-coding RNA, which … WebThe FUS gene provides instructions for making a protein that is found within the cell nucleus in most tissues and is involved in many of the steps of protein production. The FUS … impfpflicht bayern covid